Journal of clinical pharmacology
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Meta Analysis
Rash and Pruritus With PD-1 Inhibitors in Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.
We performed a systematic review and meta-analysis to fully investigate the rash and pruritus of programmed death-1 (PD-1) inhibitors in cancer patients. The relevant studies of the randomized controlled trials in cancer patients treated with PD-1 inhibitors were retrieved, and a systematic evaluation was conducted. EMBASE, MEDLINE, and PubMed were searched for articles published up to April 2018. ⋯ But both all-grade rash and pruritus varied significantly according to control therapy. The current meta-analysis suggests that the use of PD-1 inhibitors significantly increases the risk of developing all-grade rash and pruritus. Physicians should be aware of these adverse events and should monitor cancer patients who are receiving PD-1 inhibitors.