Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
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J. Oral Pathol. Med. · Mar 2012
Randomized Controlled Trial Multicenter Study Comparative StudyThe antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial.
Cytotoxic chemotherapy induces changes in the oral microflora that may cause oral and systemic infections in myelosuppressed cancer patients. These complications prompted us to assess the antimicrobial activity of a topical Iseganan HCl mouthwash vs. placebo on the aerobic and facultatively anaerobic oral flora in these patients. ⋯ Topical Iseganan HCl significantly reduces the total oral aerobic bacterial, streptococcal, and yeast load. Its potential as an oral antimicrobial agent in preventing these types of infections is clear.
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J. Oral Pathol. Med. · Mar 2012
Randomized Controlled Trial Comparative StudyEvaluation of the clinical efficacy of a betaine-containing mouthwash and an intraoral device for the treatment of dry mouth.
An evaluation is made of the efficacy and safety of an intraoral device with a betaine (BET)-containing mouthwash in treating xerostomia. ⋯ The daily use of a night guard and BET-containing mouthwash was seen to improve dry mouth during the 4-week duration of the study.