Laryngo- rhino- otologie
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Laryngo- rhino- otologie · Aug 1992
[The ototoxicity of the cytostatic drug carboplatin in patients with head-neck tumors].
The side effects of the anti-cancer drug carboplatin on the cochlea in 65 patients with head and neck cancer were examined in the present study. A possible dependence of ototoxicity on the patient's age, the effect of pre-existing audiometric changes and the carboplatin dose were investigated. ⋯ The degree of the hearing defects incurred was not influenced by the patient's age or pre-existing hearing defects but depended on the carboplatin dose used. The severity of carboplatin cochlear ototoxicity was moderate, so that no patient suffered a lack of hearing that was of social significance.