Laryngo- rhino- otologie
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Laryngo- rhino- otologie · Apr 1993
Review Case Reports[Facial paralysis in benign parotid tumor: case report and review of the literature].
Generally, typical symptoms are significant for malignant parotid tumours: The infiltration of surrounding structures and facial paralysis. A case is reported where a benign parotid tumour (lymphadenitis) caused facial paralysis. Parotidectomy and the removal of the lymph node near the stylomastoid foramen led to complete restitution. A review of the literature of the past 40 years mentions 16 cases of benign neoplasms of the parotid gland that caused facial paralysis, such as pleomorphic adenoma, Warthin's tumour, oncocytoma, benign parotid cysts, chronic parotitis, lymphadenitis and parotid abscess.
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Laryngo- rhino- otologie · Jan 1993
Comparative Study[Comparative studies of the ototoxicity of cisplatin and carboplatin].
The application of the potent anticancer drug cisplatin is limited by major side effects such as its ototoxicity and its nephrotoxicity. Since carboplatin has been introduced into clinical use, a platinum derivative with less pronounced ototoxicity and nephrotoxicity is available. ⋯ Using morphological and functional methods it could be shown that the ototoxic damage was by far higher in a group which had received a total dose of 12 kg cisplatin/kg than in a group which had received a dosage of 90 mg carboplat/kg. Our investigations show that the ototoxic potential of cisplatin in the guinea-pig is more than 9 times higher than that of carboplatin.
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Following radiotherapy of malignant head and neck tumours, tooth damage is observed in many cases, which is frequently referred to as "radiation caries". This is not the immediate result of radiation, but has a number of causes. The damage to the salivary glands caused by radiation leads to xerostomia, which affects the self-cleaning capacity in the mouth. ⋯ If preventive measures are not taken, all of the teeth can be completely destroyed within a short time. All efforts should be made to prevent this from happening, particularly in young patients who have undergone curative radiotherapy. This should include intensive fluoride treatment and meticulous oral hygiene.
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Laryngo- rhino- otologie · Aug 1992
[The ototoxicity of the cytostatic drug carboplatin in patients with head-neck tumors].
The side effects of the anti-cancer drug carboplatin on the cochlea in 65 patients with head and neck cancer were examined in the present study. A possible dependence of ototoxicity on the patient's age, the effect of pre-existing audiometric changes and the carboplatin dose were investigated. ⋯ The degree of the hearing defects incurred was not influenced by the patient's age or pre-existing hearing defects but depended on the carboplatin dose used. The severity of carboplatin cochlear ototoxicity was moderate, so that no patient suffered a lack of hearing that was of social significance.