Burns : journal of the International Society for Burn Injuries
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The aim of this study was to explore expression levels and clinical values of miR-21 and miR-210 in patients with sepsis after burns. ⋯ In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises. The miR-21 and miR-210 are related to the degree of inflammatory responses in septic patients, and their combined detection has a certain value for diagnosing the disease and predicting its prognosis.
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The most common burn wound assessment continues to be the clinical inspection and the tactile examination, which are subjective and remain challenging even for experienced burn surgeons. Recently, hyperspectral imaging camera systems have been increasingly used to support the evaluation of burn wounds. The aim of our study was to determine if hyperspectral imaging analysis differentiates and objectifies the assessment of burn wounds in burns of the upper extremities. ⋯ We found that hyperspectral imaging analysis effectively differentiates burn wounds and shows the ability to distinguish even superficial partial burns from deep partial burns in the near-infrared perfusion analysis feature. Although, it was not possible to differentiate burn wounds in all features. Currently, it is important to optimize the respective reference values of the individual burn degrees for an objectified assessment.
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Dealing with wound related pain is an integral part of treatment. Systemic administration of analgesic and anesthetic agents is a common solution for providing pain relief to patients but comes at a risk of severe side effects as well as addiction. To overcome these issues, research efforts were madeto provide a platform for local controlled release of pain killers. ⋯ The animal trials show that the RGS scores of the bupivacaine-treated group were significantly lower than these of the untreated group, proving a decrease of 51-68% in pain levels during days 1-3 after burn. Hence, successful pain reduction of spontaneous pain as well as mechanically induced pain, for at least three days after burn was achieved. It is concluded that our novel bupivacaine eluting soy protein wound dressings are a promising new concept in the field of local controlled drug release for pain management.
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The objective of this study was to make an equivalent and culturally adapted translation of an already existing scale for itching, the 5-D itch scale (5-D IS), developed as a short questionnaire and designed to measure pruritus, in order to be applied in a Spanish-speaking population. The 5-D IS consists of five sections that evaluate duration, degree, direction, disability and distribution of itching. ⋯ The result was a culturally adapted Spanish version of the 5-D IS which was then field-tested in a burn population with an internal reliability of 0,83, considered good. As pruritus and pain are bothersome symptoms present in more that 90% of burned patients during the rehabilitation phase, this culturally adapted scale allows Spanish speakers clinicians to easily objectivize the severity of pruritus and measure the impact of any intervention or treatment.
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A burn is one of the most difficult injuries people can face. The primary pathology is coagulation necrosis resulting from tissue damage. Many wound care products have been developed to be used in situations such as the poor general condition of the patient and lack of solid area to be grafted. ⋯ Histopathological examination results in no significant difference between groups in neutrophil infiltration. The difference between the groups in vascularization was statistically significant between Group II and Group V (p < 0.001) and between Group I and Group V (p = 0.005) Epithelialization was present in 75% of the rats in Group V, while no epithelialization was observed in any of the other groups. In conclusion, we observed a significant improvement in the stasis zone of the group receiving Pulsed Electromagnetic Field for two weeks.