Pharmacology, biochemistry, and behavior
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Pharmacol. Biochem. Behav. · Nov 1994
Randomized Controlled Trial Clinical TrialEffects of naloxone on the subjective and psychomotor effects of nitrous oxide in humans.
The effects of naloxone on the mood-altering and psychomotor-impairing effects of nitrous oxide were examined in two studies. Each of the double-blind, randomized trials tested effects of three doses of naloxone or saline placebo during inhalation of 30% nitrous oxide in oxygen or 100% oxygen placebo. ⋯ Naloxone had no effects by itself in either experiment, and, for the most part, did not significantly interact with nitrous oxide-induced changes in mood or psychomotor performance. Naloxone, in doses of 10 mg or less, does not appear to affect the subjective and psychomotor effects of nitrous oxide.