Pharmacology, biochemistry, and behavior
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Pharmacol. Biochem. Behav. · Sep 1994
Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis.
In Experiment 1, the 5-HT uptake blocker fluoxetine (FLX; 20 mg/kg) reduced the proportion of sexually experienced male rats displaying ejaculations. Among those animals that did ejaculate there was an increase in intromission frequency (IF), ejaculation latency (EL), and postejaculatory interval (PEI) and a reduction in copulatory efficiency (CE) during the final copulatory sequence prior to sexual exhaustion. ⋯ When FLX was given to rats with PGi lesions, it did not influence the proportion of rats ejaculating nor did it alter IF, EL, or PEI during the final copulatory series prior to exhaustion. These findings suggest that the inhibitory influences of FLX on male rat copulatory behavior are mediated in part by the interaction of FLX with neurons originating in the PGi.