Pharmacology, biochemistry, and behavior
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Pharmacol. Biochem. Behav. · May 1998
Olfactory cues and morphine-induced conditioned analgesia in rats.
In a Pavlovian conditioning procedure, rats were exposed to an odor conditioned stimulus (CS) and then were given morphine with its effect serving as the unconditioned stimulus (US). After four CS-US pairings, the CS was tested alone to assess the presence of an analgesic conditioned response (CR) using a hot-plate test. In Experiment 1a, two groups were conditioned by pairing either 10 mg/kg morphine or saline with an odor CS. ⋯ Experiment 2 characterized the dose-effect curve (0, 3, 10, and 30 mg/kg morphine) using an odor conditioning procedure. The dose-effect curve showed an inverted U-shaped function, with the 10 mg/kg morphine group having significantly longer paw-lick latencies compared to all other groups. This finding contrasts with the monotonically ascending dose-effect curve for the analgesic unconditioned response (UR) to morphine.
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Pharmacol. Biochem. Behav. · May 1998
Antagonism of ketamine-induced anesthesia by an inhibitor of nitric oxide synthesis: a pharmacokinetic explanation.
Because ketamine is an antagonist of NMDA receptors, and because some NMDA receptors activate nitric oxide synthesis in brain, this study examined if nitric oxide synthase (NOS) inhibition by L-NAME altered the course of ketamine-induced behavioral impairment. Rats given progressive doses of L-NAME until NOS activity was inhibited at least 90% displayed reduced depth and duration of behavioral depression after i.m. ketamine. ⋯ The content of norketamine and its adventitial extraction product were similarly reduced relative to control but the ratio of metabolites to ketamine was not significantly altered (p > 0.05) in brain. The decreased delivery of ketamine into brain, perhaps due to L-NAME-induced alterations in blood flow, may explain the reduced behavioral response to ketamine in these rats.