Critical reviews in food science and nutrition
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Crit Rev Food Sci Nutr · Jan 2020
Meta AnalysisThe effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials.
Background & Objectives: Inconsistent data are available about the effect of curcumin supplementation on body weight. This systematic review and meta-analysis was done to summarize data from available clinical trials on the effect of curcumin supplementation on body weight, Body Mass Index (BMI), and Waist Circumference (WC). Methods: PubMed, SCOPUS, Cochrane Library and Google Scholar were searched to find relevant articles up to August 2018. ⋯ Based on subgroup analysis, we found that the effect of curcumin on WC was significant in studies that prescribed ≥1000 mg/d curcumin (P ≤ 0.001), those with the intervention duration of ≥8 weeks (P ≤ 0.001), and those that was performed on overweight subjects (P ≤ 0.001). Conclusions: We found a significant effect of curcumin supplementation on body weight and BMI, but not on WC. However, the effect of curcumin on WC was significant in studies done on overweight subjects, used ≥1000 mg/d curcumin, and ≥8 weeks of duration.
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Crit Rev Food Sci Nutr · Jan 2019
Meta AnalysisEfficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials: Synbiotic supplementation and NAFLD.
Objective : We systematically reviewed available randomized clinical trials (RCTs) to elucidate the overall effects of synbiotic supplementation in patients with nonalcoholic fatty liver disease (NAFLD). Methods : PubMed, Scopus, ISI Web of science and Google Scholar were searched up to December, 2017. All RCTs using synbiotic supplements to treat NAFLD included in this systematic review and meta-analysis. ⋯ Our results showed that synbiotic supplementation can decrease body weight, fasting blood sugar, insulin, low density lipoprotein cholesterol, total cholesterol, triglyceride, high-sensitivity C-reactive protein, tumor necrosis factor alpha, alanine transaminase and aspartate transaminase levels among patients with NAFLD. In contrast, synbiotic did not have favorable effects on body mass index (BMI), waist circumference, homeostasis model assessment for insulin resistance (HOMA-IR), and high density lipoprotein cholesterol (HDL) levels compared with the placebo group. Conclusion : The current study revealed that synbiotic supplementation has favorable effect on inflammatory factors, liver enzymes and some anthropometric indices, lipid profiles and glucose homeostasis parameters in patients with NAFLD.
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Crit Rev Food Sci Nutr · Mar 2017
Review Meta AnalysisEffects of Quercetin Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
In spite of promising experimental findings, randomized controlled trials (RCTs) have yielded mixed results on the impact of quercetin supplementation on plasma lipid levels. ⋯ Available evidence from RCTs does not suggest any clinically relevant effect of quercetin supplementation on plasma lipids, apart from a significant reduction of triglycerides at doses above 50 mg/day.