Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
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Different mechanisms of cancer pain may involve somatic, visceral, and neural tissues. Pain that involves the neural tissues is classified as neuropathic pain and is less responsive to analgesics than pain that involves somatic and visceral tissues. ⋯ Future research is needed to characterize the intensity, location, quality, and duration of neuropathic pain in children. In addition, research that would determine the efficacy of opioids, nonsteroidal anti-inflammatory drugs, and adjuvant analgesics (antidepressants, anticonvulsants) is needed to increase the nurses' ability to assess and manage neuropathic pain in children with cancer.
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J Pediatr Oncol Nurs · Nov 2004
ReviewNurses' perceptions of phase I clinical trials in pediatric oncology: a review of the literature.
A review of literature was conducted to explore nurses' perceptions of phase I clinical trials in pediatric oncology. Specifically, nurses' perceptions of the goals and outcomes, the nurse's role, and the informed consent process in pediatric oncology phase I clinical trials were investigated. ⋯ However, despite an extensive review of published works, no studies on nurses' perceptions of phase I trials in pediatric oncology were found. Therefore, this literature review consists of findings in similar or related studies such as nurses' perceptions of experimental therapies in the adult setting, adult patients' perceptions, parents' perceptions, or oncologists'perceptions of phase I clinical trials.