Current opinion in pediatrics
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Thermal injury is a leading cause of morbidity and mortality in children. This review highlights the current management of thermal injury and its complications. ⋯ The care of pediatric patients with thermal injury is complex and multifaceted. This review highlights the most recent advances in pediatric burn care.
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Curr. Opin. Pediatr. · Jun 2020
ReviewCystic fibrosis transmembrane conductance receptor modulator therapy in cystic fibrosis, an update.
Cystic fibrosis transmembrane conductance receptor (CFTR) modulators are a new class of drugs that treat the underlying cause of cystic fibrosis. To date, there are four approved medications, which are mutation-specific. Although the number of mutations that respond to these agents is expanding, effective CFTR modulators are not available to all cystic fibrosis patients. The purpose of this article is to review the approved CFTR modulators and discuss the mutations that can be treated with these agents, as well as, review the long-term benefits of modulator therapy. ⋯ CFTR modulators are the first therapies developed to treat the underlying defect in cystic fibrosis. Their use is associated with preserved lung function and improved health in patients with cystic fibrosis.
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Children with medical or surgical critical illness or injury require skillful attention to physical, emotional, psychological, and spiritual needs, whereas their families need support and guidance in facing life-threatening or life-changing events and gut-wrenching decisions. This article reviews current evidence and best practices for integrating palliative care into the pediatric intensive care unit (PICU), with a focus on surgical patients. ⋯ This review provides a framework and tools to enable PICU and surgical providers to integrate palliative care best practices into patient and family care.