Clinical oncology : a journal of the Royal College of Radiologists
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Clin Oncol (R Coll Radiol) · Jan 1995
Case ReportsUlcerative skin reaction from subcutaneous infusion of isotonic methotrimeprazine and diamorphine.
We report an ulcerative skin reaction resulting from a subcutaneous infusion of isotonic methotrimeprazine and diamorphine. Skin reactions are a recognized side effect of this treatment, although they are reduced by the use of the isotonic formulation of methotrimeprazine. Frank ulceration has not been previously reported. It occurred in our patient despite low doses of diamorphine and methotrimeprazine, an isotonic formulation, and a short infusion time.
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Clin Oncol (R Coll Radiol) · Jan 1995
Does dexamethasone leucocytosis facilitate full dosage adjuvant chemotherapy for breast cancer?
This is a retrospective analysis of breast cancer patients given adjuvant 'CMF' cytotoxic chemotherapy. It examines the impact on full blood counts of introducing dexamethasone as a prophylactic antiemetic the day before injections. ⋯ Twelve of 13 patients treated before the introduction of prophylactic dexamethasone, but only eight of 21 patients treated after, experience dose reduction or delay due to leucopenia (P < 0.01). Dexamethasone facilitated the administration of chemotherapy according to schedule.