European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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Eur Arch Otorhinolaryngol · May 2010
Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery.
This study was aimed to compare the intraoperative sedative and perioperative analgesic drug requirements and the incidences of postoperative side effects on the patients who received preoperative gabapentin or placebo. Sixty patients undergoing nasal septal or nasal sinus surgery were included. The patients received either 600 mg gabapentin (Group G) or placebo (Group P) orally, 1 h before surgery. ⋯ Time to first request for analgesic was 12.7 + or - 2.3 h in Group G, and 7.8 2.1 h in Group P (P < 0.0001). Total consumption of lornoxicam was lower in Group G (P < 0.004). We concluded that monitored anesthesia care combined with preoperative analgesia with a low dose of (600 mg) oral gabapentin is an efficient option with tolerable side effects for patients undergoing ear, nose and throat ambulatory surgery.
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Lidocaine has been used as an injection or spray solution to protect spasm reaction during tracheal intubation and bronchoscopy. The effect of lidocaine for local anesthesia is well known. However, the effect of the drug to tracheal smooth muscle is not well explored. ⋯ Using the same concentration, the drug also could totally inhibit the electrical field stimulation-induced spike contraction. Lidocaine elicited a negligible response to the resting tension of trachea as the concentration increased. The study indicated that lidocaine could cause bronchodilation not only from blocking parasympathetic tone, but also from directly antagonizing the effect of cholinergic receptors.