The British journal of dermatology
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Randomized Controlled Trial Multicenter Study Clinical Trial
Treatment of psoriasis with oral liarozole: a dose-ranging study.
Liarozole is an inhibitor of the metabolism of all-trans-retinoic acid. Systemic administration increases tissue levels of this endogenous retinoid and has been reported to improve psoriasis in an open, uncontrolled study. ⋯ The data confirm that liarozole is an effective treatment for psoriasis and indicate that the lowest effective dose is 75 mg twice daily. The drug seems generally to be well tolerated.