European journal of internal medicine
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Eur. J. Intern. Med. · Jun 2020
Alcohol consumption and risk of incident atrial fibrillation: A population-based cohort study.
Atrial fibrillation (AF) is a common tachyarrhythmia. High alcohol consumption is associated with increased AF risk. It remains unclear whether lower levels of alcohol consumption are also associated with AF risk, and whether the association differs between men and women. In this study, we investigated the association between low to moderate levels of alcohol consumption and AF risk in men and women. ⋯ Self-reported alcohol consumption and problem drinking were associated with an increased risk of AF among men, but not in women.
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Eur. J. Intern. Med. · Jun 2020
Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia.
Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. ⋯ Tocilizumab results to have a positive impact if used early during Covid-19 pneumonia with severe respiratory syndrome in terms of increased survival and favorable clinical course.
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Eur. J. Intern. Med. · Jun 2020
Clinical outcomes and need for intensive care after non-ST-segment-elevation myocardial infarction.
The decision on whether non-ST-segment elevation myocardial infarction (NSTEMI) patients should be admitted to intensive care units (ICU) takes into account several factors including hospital routines. The Acute Coronary Treatment and Intervention Outcomes Network (ACTION) ICU score was developed to predict complications requiring ICU care post-NSTEMI. ⋯ Complications requiring ICU care were infrequent in a cohort of NSTEMI patients who were routinely admitted to the ICU over a 4-year period. The ACTION risk score had low accuracy in the prediction of complications requiring ICU care in our population.
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Eur. J. Intern. Med. · Jun 2020
Acidosis predicts mortality independently from hyperlactatemia in patients with sepsis.
Acidosis and hyperlactatemia predict outcome in critically ill patients. We assessed BE and pH for risk prediction capabilities in a sub-group of septic patients in the MIMIC-III database. ⋯ Acidosis and hyperlactatemia can occur independently to a certain degree. Combining acidosis and hyperlactatemia in a model yielded higher predictiveness for ICU-mortality. Septic patients with acidosis should be treated even more aggressively in the future.