European journal of internal medicine
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Eur. J. Intern. Med. · Apr 2022
Meta AnalysisMortality and its risk factors in critically ill patients with connective tissue diseases: A meta-analysis.
Systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM) and rheumatoid arthritis (RA) are connective tissue diseases (CTD) whose complications can lead to management in the intensive care unit (ICU). ⋯ The overall pooled proportion of mortality of ICU patients with CTD was 33% (95%CI: 28-38%), with a high heterogeneity (I2= 89%). In the subgroup analysis, mortality was higher for patients with IIM and SSc.
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Eur. J. Intern. Med. · Apr 2022
Critical appraisal of international adult bronchiectasis guidelines using the AGREE II tool.
Guidelines aim to standardize and optimize diagnosis and management. We evaluated the quality of evidence supporting recommendations from different international adult guidelines on bronchiectasis, and classified with the GRADE system. ⋯ Updated guidelines reported after 2017 improved quality, although well-designed randomized clinical trials remain an unmet need. AGREE II quality assessment identified four guidelines qualified as recommended for use. Improvements are required in stakeholder involvement and applicability.
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Eur. J. Intern. Med. · Apr 2022
Truly unexplained falls after evaluation for syncope: A new diagnostic entity with severe prognosis.
To compare one-year mortality risk associated with syncope and unexplained fall in older adults with dementia. ⋯ We propose the novel diagnostic category of "Truly Unexplained Fall", resulting from the application of syncope guidelines to subjects with unexplained falls. This condition in older adults with dementia is a predictor of one-year all-cause mortality. For this new high risk profile, we advice a comprehensive geriatric assessment focused on risk factors for fall, aimed at a possible improvement of prognosis.