European journal of internal medicine
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Eur. J. Intern. Med. · Sep 2024
Carotid plaque offsets sex-related differences in cardiovascular risk of young hypertensive patients.
Women have a lower risk for cardiovascular (CV) disease compared to men. Whether this difference is influenced by the presence of hypertension-mediated organ damage is unknown. ⋯ Our findings suggest that the presence of CP in young patients with treated hypertension offsets the CV disease protection in women.
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Eur. J. Intern. Med. · Sep 2024
Impaired insulin sensitivity measured by estimated glucose disposal rate is associated with decreased myocardial mechano-energetic efficiency in non-diabetic individuals.
Impaired myocardial mechano-energetic efficiency (MEE) has been associated with cardiac insulin resistance measured by dynamic positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) combined with euglycemic-hyperinsulinemic clamp. Estimate glucose disposal rate (eGDR) index has a good correlation with whole-body insulin sensitivity. It remains unsettled whether eGDR index is a suitable proxy of cardiac insulin sensitivity as well as its association with myocardial MEE. The aims of this study were: 1) to compare eGDR index with HOMA-IR, QUICKI and FIRI indexes for association with myocardial glucose metabolic rate (MrGlu); and 2) to determine the association of eGDR index with myocardial MEE. ⋯ These data suggest that the eGDR index may be a useful marker to identifying individuals at high cardiovascular risk.