European journal of cancer : official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
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Review Meta Analysis
Randomised controlled trials in oncology closed early for benefit: trends in methodology, results, and interpretation.
To assess methodology, results and interpretation of oncology randomised controlled trials closed early for benefit (RCTCEB). ⋯ While the majority of oncology RCTCEB follows rigourous methodological principles, an important percentage includes limitations in design and/or analysis. Amongst the 23 studies with subsequent follow-up reports, initial results were confirmed in 22 (96%).