Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Nov 1991
Randomized Controlled Trial Comparative Study Clinical TrialIntravenous ketamine for prevention of severe hypotension during spinal anaesthesia.
Spinal block causes paralysis of preganglionic sympathetic fibres, while ketamine induces activation of the sympathetic nervous system. Hypotension is a frequent complication during spinal anaesthesia and is associated with an increased risk of postoperative mortality. The aim of our study was to compare circulatory changes in patients who received either fentanyl or ketamine during spinal anaesthesia. ⋯ In the fentanyl group six subjects developed a haemodynamically unstable condition, while only one subject in the ketamine group was registered as such (P less than 0.05). There was no significant change in heart rate in either group. We conclude that during spinal anaesthesia patients can in part be kept haemodynamically stable by intravenous administration of ketamine.
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We studied 21 patients undergoing lumbar spinal surgery under halothane anesthesia on a convex saddle frame, in order to determine the hemodynamic effect of the prone position. A thermodilution pulmonary arterial catheter was placed in 14 patients (Group PA-1: n = 8; and Group PA-2: n = 6), and an inferior vena caval catheter in the remaining seven patients (Group IVC). Group PA-1 and Group IVC patients were placed in the prone position on a convex saddle frame. ⋯ Then the convex curvature of the frame was adjusted to the grade appropriate for surgery, which produced a significant reduction in CI (from 2.9 +/- 0.3 to 2.4 +/- 0.4, P less than 0.05). We conclude that the prone position itself may not interfere with the circulatory function. The prone position using a convex saddle frame causes significant reductions in CI, but little change in the other hemodynamic variables.
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Acta Anaesthesiol Scand · Nov 1991
Gas flow distribution in distal high frequency jet ventilation and lung thorax compliance.
To investigate the influence of changes in thorax and lung compliance on ventilation during distal High Frequency Jet Ventilation (HFJV), similar ventilator settings were compared before and after changing the compliance in two groups of anaesthetized mongrel dogs. Each period of distal HFJV was preceded by adequate Intermittent Positive Pressure Ventilation (IPPV) to assure a start with baseline values. In Group 1 (n = 7), thorax compliance was changed by chest strapping, while in Group 2 (n = 7) lung compliance was changed by inducing acute lung injury by injection of oleic acid into the right atrium. ⋯ Comparing similar ventilator settings during distal HFJV in the same dog, a decrease in lung or thorax compliance led to changes in gas flow distribution in the ventilatory circuit. Entrainment was decreased and bypass increased with a negative effect on the gas volume entering the lungs and on gas exchange. The results indicate that distal HFJV should be regarded as pressure-limited ventilation.
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Acta Anaesthesiol Scand · Nov 1991
Randomized Controlled Trial Comparative Study Clinical TrialOpioid supplementation to propofol anaesthesia for outpatient abortion: a comparison between alfentanil, fentanyl and placebo.
One hundred and sixty-four patients scheduled for elective termination of pregnancy under general anaesthesia were randomly assigned to receive one of three different supplements to propofol and oxygen in nitrous oxide anaesthesia: 0.1 mg fentanyl, 0.5 mg alfentanil or placebo. Postoperative pain and nausea, as well as complications during anaesthesia were studied. There were no differences in complications or complaints by surgeons during anaesthesia, and no patient in any group reacted unsatisfactorily to surgery. ⋯ In conclusion, opioid supplementation lowered the amount of propofol needed for anaesthesia. Alfentanil 0.5 mg did not improve the postoperative course. Fentanyl 0.1 mg decreased the frequency of postoperative pain without increasing the time to hospital discharge.
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Acta Anaesthesiol Scand · Nov 1991
Comparative StudyA comparison of median frequency, spectral edge frequency, a frequency band power ratio, total power, and dominance shift in the determination of depth of anesthesia.
Five numerical descriptors were derived from the electroencephalogram (EEG), recorded, and processed (Tracor Nomad) during emergence from isoflurane-nitrous oxide anesthesia. The five descriptors (median frequency, spectral edge frequency-90%, total power, a frequency band power ratio, and the ratio of frontal to occipital power) were compared for their ability to predict imminent arousal. Arousal was defined as spontaneous movement, coughing or eye opening. ⋯ For median frequency, spectral edge frequency-90%, total power, and the frequency band power ratio, thresholds that predicted imminent arousal with sensitivities of 90% and specificities of 82-90% could be identified. The data indicate that, even in the favorable circumstances of the present study (uniform anesthetic technique, post hoC identification of thresholds), none of several previously popularized EEG descriptors (median frequency, spectral edge frequency-90%, total power, a frequency band power ratio) can serve as a completely reliable sole predictor of imminent arousal. As presently derived, these EEG descriptors at best provide trend information to be used in concert with other clinical signs of depth of anesthesia.