Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 1996
Results of in vitro contracture testing of both parents of malignant hyperthermia susceptible probands.
Malignant Hyperthermia (MH) is regarded as a dominantly inherited condition. Therefore, most investigators do not test the second parent if the first parent is found to be MH susceptible (MHS). The purpose of this study was to validate this policy. ⋯ We conclude that both parents should be tested whenever possible. For genetic research it is important that labelling any parent "presumed normal" may give misleading results.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialReduced hypoxic chemosensitivity in partially paralysed man. A new property of muscle relaxants?
It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man. ⋯ It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialPostoperative pain relief by topical lidocaine in the surgical wound of hysterectomized patients.
To improve postoperative analgesia, local anesthetics have been administered perioperatively as infiltration or as aerosol in the surgical area. A previous study showed good analgesic effects by topical lidocaine in the wound in minor extraabdominal surgery (herniorraphy), while the same treatment in minor lower laparothomies did not improve postoperative analgesia. The present study investigated the effect of topical wound anesthesia using lidocaine aerosol on postoperative pain following major lower abdominal surgery. ⋯ A single dose of lidocaine aerosol topically administered in the surgical wound of hysterectomy patients improved analgesia during the first postoperative day with minimal risk of side effects.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialPatient-controlled analgesia with morphine and droperidol following caesarean section under spinal anaesthesia.
The addition of droperidol to morphine for patient-controlled analgesia reduces the incidence of nausea and vomiting, but may result in unwanted side effects. ⋯ The addition of droperidol 10 mg to morphine 60 mg for PCA following caesarean section under spinal anaesthesia reduces the incidence of nausea and emesis, but may result in drowsiness, limiting the usefulness of the technique.
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Acta Anaesthesiol Scand · May 1996
Continuous non-invasive monitoring of energy expenditure, oxygen consumption and alveolar ventilation during controlled ventilation: validation in an oxygen consuming lung model.
We have developed a combined indirect calorimetric and breath-by-breath capnographic device (GEM) for respiratory monitoring: oxygen consumption (VO2), carbon dioxide excretion (VCO2), respiratory quotient (RQ), energy expenditure (EE), alveolar ventilation (VA) and dead space/total ventilation (VD/VT). ⋯ The overall performance of the device is satisfactory and well comparable with any equipment tested. It allows near-continuous non-invasive monitoring of EE, VO2, VCO2, VA, VD/VT in ventilated, critically ill patients, providing a rationale for ventilator settings and nutritional support.