Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialConditions to optimise the reversal action of neostigmine upon a vecuronium-induced neuromuscular block.
Since neostigmine was introduced for reversal of neuromuscular block, there has been controversy about the optimum dose for antagonizing neuromuscular block. The purpose of this study was to characterise recovery of neuromuscular transmission following a vecuronium-induced block 15 min after neostigmine administration using different stimulation patterns, and to determine the effects of different doses of neostigmine given at various pre-reversal twitch heights. ⋯ To optimise the reversal action of neostigmine in order to obtain the highest neuromuscular transmission recovery (0.9 TOF ratio and RF100Hz) during a vecuronium-induced neuromuscular block, the 40 micrograms/kg dose has to be given at 25 to 50% recovery of TH.
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Acta Anaesthesiol Scand · May 1996
Continuous non-invasive monitoring of energy expenditure, oxygen consumption and alveolar ventilation during controlled ventilation: validation in an oxygen consuming lung model.
We have developed a combined indirect calorimetric and breath-by-breath capnographic device (GEM) for respiratory monitoring: oxygen consumption (VO2), carbon dioxide excretion (VCO2), respiratory quotient (RQ), energy expenditure (EE), alveolar ventilation (VA) and dead space/total ventilation (VD/VT). ⋯ The overall performance of the device is satisfactory and well comparable with any equipment tested. It allows near-continuous non-invasive monitoring of EE, VO2, VCO2, VA, VD/VT in ventilated, critically ill patients, providing a rationale for ventilator settings and nutritional support.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialPostoperative pain relief by topical lidocaine in the surgical wound of hysterectomized patients.
To improve postoperative analgesia, local anesthetics have been administered perioperatively as infiltration or as aerosol in the surgical area. A previous study showed good analgesic effects by topical lidocaine in the wound in minor extraabdominal surgery (herniorraphy), while the same treatment in minor lower laparothomies did not improve postoperative analgesia. The present study investigated the effect of topical wound anesthesia using lidocaine aerosol on postoperative pain following major lower abdominal surgery. ⋯ A single dose of lidocaine aerosol topically administered in the surgical wound of hysterectomy patients improved analgesia during the first postoperative day with minimal risk of side effects.
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Acta Anaesthesiol Scand · May 1996
Results of in vitro contracture testing of both parents of malignant hyperthermia susceptible probands.
Malignant Hyperthermia (MH) is regarded as a dominantly inherited condition. Therefore, most investigators do not test the second parent if the first parent is found to be MH susceptible (MHS). The purpose of this study was to validate this policy. ⋯ We conclude that both parents should be tested whenever possible. For genetic research it is important that labelling any parent "presumed normal" may give misleading results.
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Acta Anaesthesiol Scand · May 1996
Case ReportsTransfusion-related acute lung injury (TRALI) after fresh frozen plasma in a patient with coagulopathy.
Transfusion-related acute long injury (TRALI) is due to specific antigen-antibody reaction involving the donor's leucocyte or granulocyte antibodies towards the recipient's antigens. Aggregation in small pulmonary vessels occurs, leading to derangement of permeability. ⋯ When TRALI is suspected the donor blood has to be tested against the recipient. Ventilatory support of the patient is continued until adequate oxygenation is reached.