Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialReduced hypoxic chemosensitivity in partially paralysed man. A new property of muscle relaxants?
It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man. ⋯ It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.
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Acta Anaesthesiol Scand · May 1996
Recall of awareness during cardiac anaesthesia: influence of feedback information to the anaesthesiologist.
We interviewed 303 cardiac surgery patients to evaluate the incidence of intraoperative awareness with recall. First, we randomly interviewed 99 patients, of whom four patients (4%) reported awareness and recall. We informed the cardiac anaesthesiologists of the results of these interviews, and we also gave general information regarding means to reduce awareness and recall during general anaesthesia. ⋯ The patients with awareness were significantly younger than those not aware. In conclusion, with educational measures and vigilance over the problem, the incidence of intraoperative awareness during cardiac anaesthesia may be reduced. The incidence figure of 1.5% we observed is of the magnitude reported recently by others with modern cardiac anaesthesia techniques.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialNo additional analgesic effect of intra-articular morphine or bupivacaine compared with placebo after elective knee arthroscopy.
Intra-articular pain prophylaxis is a controversial measure, adding costs although the benefits are still disputed. We wanted to evaluate the effects of intra-articular opioid or local anaesthesia or a combination of the two on postoperative analgesia and analgesic consumption after elective knee arthroscopy. ⋯ Intra-articular administration of morphine or bupivacaine is not indicated after elective knee-arthroscopy in patients with minor pre-operative pain and a small surgical trauma.
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Acta Anaesthesiol Scand · May 1996
Continuous non-invasive monitoring of energy expenditure, oxygen consumption and alveolar ventilation during controlled ventilation: validation in an oxygen consuming lung model.
We have developed a combined indirect calorimetric and breath-by-breath capnographic device (GEM) for respiratory monitoring: oxygen consumption (VO2), carbon dioxide excretion (VCO2), respiratory quotient (RQ), energy expenditure (EE), alveolar ventilation (VA) and dead space/total ventilation (VD/VT). ⋯ The overall performance of the device is satisfactory and well comparable with any equipment tested. It allows near-continuous non-invasive monitoring of EE, VO2, VCO2, VA, VD/VT in ventilated, critically ill patients, providing a rationale for ventilator settings and nutritional support.
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Acta Anaesthesiol Scand · May 1996
Results of in vitro contracture testing of both parents of malignant hyperthermia susceptible probands.
Malignant Hyperthermia (MH) is regarded as a dominantly inherited condition. Therefore, most investigators do not test the second parent if the first parent is found to be MH susceptible (MHS). The purpose of this study was to validate this policy. ⋯ We conclude that both parents should be tested whenever possible. For genetic research it is important that labelling any parent "presumed normal" may give misleading results.