Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 1997
Randomized Controlled Trial Clinical TrialInclusion of pethidine in lidocaine for infiltration improves analgesia following tonsillectomy in children.
Previous work has demonstrated that pethidine exerts local anaesthetic effects on peripheral nerves in vivo. We examined the effects of infiltration anaesthesia by a combination of pethidine and lidocaine on post-tonsillectomy pain and restlessness in children. ⋯ Inclusion of a low dose of pethidine in lidocaine for tonsillar infiltration improves pain relief after tonsillectomy in children.
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Acta Anaesthesiol Scand · Feb 1997
Paediatric cardiac arrest and resuscitation provided by physician-staffed emergency care units.
Most paediatric cardiac arrest studies have been conducted in the USA, where paramedics provide prehospital emergency care. We wanted to study the outcome of paediatric cardiac arrest patients in an emergency medical system which is based on physician staffed emergency care units. ⋯ Although prehospital care was provided by physicians, the overall rate of survival was found to be equally poor as reported from systems with paramedics. The only major difference between physician- and paramedic-staffed emergency care units is the ability of physicians to refrain from resuscitation already on the scene when prognosis is poor.
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Acta Anaesthesiol Scand · Feb 1997
Wound infiltration with liposomal bupivacaine prolongs analgesia in rats.
Wound infiltration with local anesthetics does not reliably produce satisfactory postoperative analgesia, and the dose of local anesthetic which may be safely administered is limited by the potential for systemic toxicity. This study evaluated the efficacy of a slow-release liposomal bupivacaine formulation on duration of wound analgesia. ⋯ The 8-fold increase in duration of wound analgesia and the lower plasma levels seen with the liposomal formulation are explained by gradual drug release from the liposomal depot. These results may have important implications for achieving safe and effective analgesia with wound infiltration techniques in humans.
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Acta Anaesthesiol Scand · Feb 1997
Randomized Controlled Trial Clinical TrialIntraperitoneal bupivacaine for analgesia after laparoscopic cholecystectomy.
The effects of intraperitoneal administration of bupivacaine on pain after laparoscopic cholecystectomy were studied in a prospective, double-blind, randomised trial. ⋯ We conclude that reducing pain with intraperitoneal bupivacaine is effective, easy to administer, and without side-effects.
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Acta Anaesthesiol Scand · Feb 1997
Randomized Controlled Trial Clinical TrialMetoclopramide reduces the induction dose of propofol.
Metoclopramide has been shown to reduce the dose of thiopentone required for induction of anaesthesia. When propofol is used, there have been conflicting results with one small study showing a reduction in the anaesthetic dose and one study failing to demonstrate any effect. ⋯ The mechanism of reduction of propofol dose by metoclopramide is unknown; it may involve GABA or result from a more complex interaction involving dopamine blockade by metoclopramide.