Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Nov 1998
Randomized Controlled Trial Comparative Study Clinical TrialRespiration during emergence from anaesthesia with desflurane/N2O vs. desflurane/air for gynaecological laparoscopy.
The complications related to anaesthesia usually occur in the early postoperative period. Hypercapnia and hypoxaemia may result from any persistent depression of the respiratory drive relative to the metabolic demand. The purpose of this study was to compare the respiratory effects of desflurane anaesthesia with or without nitrous oxide during the period of emergence. ⋯ The respiratory profiles during recovery from gynaecological laparoscopy with either desflurane/N2O or desflurane anaesthesia were similar with fast resumption of spontaneous breathing, short time to extubation, and no signs of CO2 retention.
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Acta Anaesthesiol Scand · Nov 1998
Randomized Controlled Trial Clinical TrialIs the recovery profile of mivacurium independent of the rate of decay of its plasma concentration in patients with normal plasma cholinesterase activity?
The duration of action of muscle relaxants is poorly correlated to the rate of decay of their plasma concentration. The plasma concentration of mivacurium may rapidly decrease below its active concentration because of the extensive hydrolysis of mivacurium. By inflating a tourniquet on one upper limb for 3 min after the administration of atracurium, mivacurium or vecuronium, we studied the influence of the initial decline of their plasma concentration on their effect. ⋯ The results suggest that the rate of decline of the plasma concentration of mivacurium is so rapid, that a very low and almost clinically ineffective concentration is present as soon as 3 min after its administration. The results also indicate that the recovery from a mivacurium-induced neuromuscular blockade is not influenced by the rate of decay of its plasma concentration in patients with genotypically normal plasma cholinesterase.
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Acta Anaesthesiol Scand · Nov 1998
Multicenter Study Clinical TrialEffect of learning during an anaesthesiological multicentre trial.
After the completion of a multicentre study, it was disputed whether becoming acquainted with a novel drug would affect dosing, and how many consecutive patients would be sufficient for this phenomenon. ⋯ This study shows that the learning effect can influence the results in a multicentre study. Learning contamination may occur if a novel drug is dosed by clinical judgement, and if the allocation of patients into groups is markedly uneven during the different stages of the study.
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Acta Anaesthesiol Scand · Nov 1998
Effect of CPAP during cardiopulmonary bypass on postoperative lung function. An experimental study.
Respiratory failure secondary to cardiopulmonary bypass (CPB) remains a major complication after cardiac surgery. We tested the hypothesis that post-CPB lung function impairment can be prevented by continuous positive airway pressure (CPAP) applied during the CPB. ⋯ We conclude that in this pig model post-CPB atelectasis is not effectively prevented by CPAP applied during CPB.
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Acta Anaesthesiol Scand · Nov 1998
Use of the laryngeal mask airway during ophthalmic surgery results in stable circulation and few complications: a prospective audit.
This study was performed to investigate airway complications related to Laryngeal Mask Airway (LMA) use in a selected group of paediatric patients undergoing ophthalmic surgery. ⋯ LMA can be regarded as a safe product for airway maintenance during ophthalmic surgery with a stable circulation and few complications.