Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 1998
Randomized Controlled Trial Clinical TrialThe analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans.
Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed. Chronic ischemic pain due to lower extremity arteriosclerosis obliterans often responds poorly to analgesics, and the pain-generating mechanisms are not well understood. ⋯ We have demonstrated a potent dose-dependent analgesic effect of racemic ketamine in clinical ischemic pain. Due to a narrow therapeutic window, this analgesic effect is probably best utilised in combination with other analgesics.
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Acta Anaesthesiol Scand · Aug 1998
Comparative StudyA bolus dose of 1.5 mg/kg amrinone effectively improves low cardiac output state following separation from cardiopulmonary bypass in cardiac surgical patients.
The aim of this study was to evaluate the efficacy of 1.5 mg/kg bolus of amrinone on low cardiac output (CO) state following emergence from cardiopulmonary bypass (CPB) in cardiac surgical patients. ⋯ A 1.5 mg/kg amrinone loading dose to patients in a low CO state, despite catecholamine therapy immediately after emergence from CPB, effectively improves ventricular function when loading conditions are maintained constant.
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Acta Anaesthesiol Scand · Aug 1998
Randomized Controlled Trial Comparative Study Clinical TrialPostural post-dural puncture headache after spinal and epidural anaesthesia. A randomised, double-blind study.
This study was conducted in order to investigate the effect of patient expectation in the development of postural post-dural puncture headache (PPDPH). ⋯ SA gave more headache but superior quality of surgical anaesthesia compared with EA. Dural puncture, and not expectation, is the major cause of PPDPH.
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Acta Anaesthesiol Scand · Aug 1998
Randomized Controlled Trial Comparative Study Clinical TrialAnalgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy.
Tonsillectomy is a common procedure in childhood resulting in significant morbidity due to pain. The aim of this study was to evaluate the analgesic efficacy and safety of a single dose of ketorolac i.v. given before or after tonsillectomy, compared to placebo. ⋯ This study indicates that a single dose of ketorolac 1 mg.kg-1 i.v. administered either before or immediately after surgery improves postoperative analgesia in children after tonsillectomy without evidence of increased incidence of bleeding.