Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 1998
Inhibited hypothalamic histamine metabolism during isoflurane and sevoflurane anesthesia in rats.
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate the effects of isoflurane and sevoflurane anesthesia on hypothalamic histamine metabolism. ⋯ Histamine metabolism was inhibited during both isoflurane and sevoflurane anesthesia and accelerated only in the posterior hypothalamus during the emergence from these anesthetics.