Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2001
Randomized Controlled Trial Clinical TrialRopivacaine 1 mg x ml(-1) does not decrease the need for epidural fentanyl after hip replacement surgery.
Ropivacaine is a new long-acting local anesthetic. Laboratory trials have demonstrated a synergistic analgesic effect between intrathecal opioids and local anesthetics. We tested the hypothesis that addition of ropivacaine 1 mg x ml(-1) to epidural fentanyl (10 microg x ml(-1)) postoperatively decreases the need for fentanyl, improves the quality of analgesia and decreases the side-effects of fentanyl. ⋯ Addition of ropivacaine 1 mg x ml(-1) to epidural fentanyl 10 microg x ml(-1) did not significantly decrease the requirement for fentanyl administered for pain relief after hip replacement surgery.
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Acta Anaesthesiol Scand · Apr 2001
Randomized Controlled Trial Comparative Study Clinical TrialTotal knee replacement: a comparison of ropivacaine and bupivacaine in combined femoral and sciatic block.
Femoral and sciatic nerve block may improve post-operative analgesia following total knee replacement. ⋯ Femoral and sciatic blockade following intrathecal bupivacaine/diamorphine provided superior analgesia when compared with intrathecal bupivacaine/diamorphine alone. There were no significant clinical differences between the group receiving bupivacaine 7.5 mg x ml(-1) and the group receiving ropivacaine 7.5 mg x ml(-1).
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Acta Anaesthesiol Scand · Apr 2001
Randomized Controlled Trial Clinical TrialEffects of olprinone, a new phosphodiesterase inhibitor, on gastric intramucosal acidosis and systemic inflammatory responses following hypothermic cardiopulmonary bypass.
Phosphodiesterase (PDE) III inhibitors have both an inotropic and a peripheral vasodilatory effect, and also inhibit the activation of macrophages. Thus a newly developed PDE III inhibitor, olprinone, could modify gastric intramucosal pH (pHi), systemic oxygen consumption, and systemic inflammatory responses in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). ⋯ Our results suggest that olprinone at 0.2 microg x kg(-1) x min(-1) suppresses gastric intramucosal acidosis and systemic inflammation following CPB.
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Acta Anaesthesiol Scand · Apr 2001
Retracted PublicationRetracted: Price development in important anesthesia and critical care medicine journals in comparison to journals of other disciplines.
In today's climate of financial restrictions, libraries and individual subscribers complain about the price increase of scientific journals. The development in prices of anesthesia/critical care journals was analysed over the past 6 years and compared to prices of some journals of other disciplines. ⋯ A disproportionate rise in journal prices was seen over the past 6 years. The large increase in cost may have multiple reasons. The rapidly increasing cost of research journals may affect research quality because economic pressure may result in reduction in availibility of information due to cancellation of subscriptions to journals.
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Acta Anaesthesiol Scand · Apr 2001
Randomized Controlled Trial Comparative Study Clinical TrialPatient-controlled epidural analgesia versus continuous epidural analgesia after total knee arthroplasty.
Patient-controlled epidural analgesia (PCEA) has been found to be an effective method for pain relief during labour and after surgery. The goal of this study was to compare the efficacy of bupivacaine-fentanyl PCEA and continuous epidural infusion with the same mixture for treatment of pain after total knee arthroplasty. ⋯ The amount of bupivacaine-fentanyl solution consumed was significantly less with PCEA than with continuous infusion of bupivacaine-fentanyl solution without affecting the quality of postoperative analgesia after total knee arthroplasty. Several of the elderly patients had difficulties in operating the PCEA apparatus.