Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Nov 2004
Randomized Controlled Trial Comparative Study Clinical TrialClonidine vs. midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial.
Clonidine administration in the setting of paediatric anaesthesia is associated with a number of desirable effects, e.g. preoperative sedation, analgesia and reduced anaesthetic requirements. The aim of the current study was to compare postoperative outcome variables using a prospective, randomized, double-blind design after premedication with clonidine or midazolam. ⋯ Rectal premedication with clonidine was associated with a significant reduction of pain in the early postoperative period compared to midazolam and was also associated with moderately increased sedation during the first 24 postoperative hours. The sedative effect of clonidine is in agreement with the unambiguous finding of a parental preference for a calm and sedated child during the first 24 postoperative hours.
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Acta Anaesthesiol Scand · Nov 2004
Comment Historical ArticleFurther commentary on Denmark's 1952-53 poliomyelitis epidemic, especially regarding mortality; with a correction.
Berthelsen and Cronqvist recently published an article in Acta Anaesthesiologica Scandinavica including aspects which could lead on to further discussion about the Danish 1952-53 poliomyelitis epidemic. This paper considers how Bjørn Ibsen's initial approach to treatment during the epidemic was successful, as well as how it could have failed; the roles played by ventilatory failure vs. gross neurologic destruction in causing deaths; and compilations from publications of statistics concerning mortality of the epidemic. The Blegdam Hospital concept of 'life-threatening poliomyelitis' is revisited, along with its division into six anatomico-clinical categories for the 345 patients so classified. ⋯ Lassen, has been freely used. Some folklore about aspects of management is mentioned. In the light of other recent research by Dr Berthelsen an essential correction is needed in dating 'Bjørn Ibsen's Day', amending 26 August 1952 to the 27th.
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Acta Anaesthesiol Scand · Nov 2004
Randomized Controlled Trial Clinical TrialDixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.
The study assessed the efficacy and safety of dixyrazine, an alternative neuroleptic drug to droperidol, in the prophylaxis of postoperative nausea and vomiting (PONV). ⋯ Prophylactic dixyrazine is an effective, safe, and cheap antiemetic drug for laparoscopic cholecystectomy without involving any significant adverse events.
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Acta Anaesthesiol Scand · Nov 2004
Randomized Controlled Trial Comparative Study Clinical TrialWomen report more pain on injection of a precurarization dose of rocuronium: a randomized, prospective, placebo-controlled trial.
The purpose of this study was to investigate whether gender influences the perception of pain on injection of rocuronium. ⋯ Women experienced more pain on injection of rocuronium than men, moreover this is an additional evidence for gender-related differences in pain perception. When rocuronium is used as a precurarization agent, an analgesic pretreatment (e.g. opioids) should be considered, especially for female patients.
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Acta Anaesthesiol Scand · Nov 2004
Randomized Controlled Trial Comparative Study Clinical TrialComparison of the analgesic efficacy of ketobemidone and morphine for management of postoperative pain in children: a randomized, controlled study.
Ketobemidone has been used as an analgesic for postoperative pain in children, but to our knowledge the effect and occurrence of adverse effects of ketobemidone compared to morphine is not known. The aim was to determine if the analgesic potency and the occurrence of adverse effects of ketobemidone differ from morphine when administered to children, as measured by patient-controlled analgesia consumption (PCA) for postoperative pain. ⋯ The analgesic potency and adverse effects of ketobemidone are similar to morphine when used for postoperative pain management in children.