Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2004
Adrenaline administration during cardiopulmonary resuscitation: poor adherence to clinical guidelines.
Adrenaline does not appear to improve the outcome after cardiac arrest in clinical trials in spite of beneficial effects in experimental studies. The objective of this study was to determine whether adrenaline was administered in accordance with advanced cardiac life support (ACLS) guidelines during adult cardiopulmonary resuscitation (CPR). ⋯ In the majority of cases adrenaline did not appear to be administered according to current ACLS guidelines.
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Acta Anaesthesiol Scand · Aug 2004
Randomized Controlled Trial Clinical TrialIntrathecal morphine provides effective and safe analgesia in children after cardiac surgery.
The purpose of this prospective, randomized, blinded to observer study was to assess the analgesic effect and safety of intrathecal morphine (ITM) in post-operative pain control in children after heart surgery with a sternotomy incision. ⋯ An ITM dose of 20 micrograms/kg had a significant (P = 0.03) intravenous morphine-sparing effect after cardiac surgery. Effective analgesia was observed for 12 h after administration of intrathecal morphine.
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Acta Anaesthesiol Scand · Aug 2004
Randomized Controlled Trial Clinical TrialIs a double-injection technique superior to a single injection in posterior subgluteal sciatic nerve block?
Currently, no information is available on the effects of a double-injection technique on onset time and efficacy following subgluteal sciatic nerve blockade. We hypothesized that the success rate and time to onset of subgluteal nerve block following a double-injection technique would be superior to that after a single injection. ⋯ Both the single- and double-injection technique for subgluteal sciatic nerve blockade resulted in acceptable anesthesia in most patients. The double injection generated a faster onset of anesthesia than the single injection. However, the double-injection technique caused more patient discomfort during establishment of the nerve block.
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Acta Anaesthesiol Scand · Aug 2004
Randomized Controlled Trial Clinical TrialEarly bioavailability of paracetamol after oral or intravenous administration.
Paracetamol is a peripherally acting analgesic commonly used in multimodal post-operative pain management to reduce the need for more potent analgesics with their unwanted side-effects. The dose and optimal galenical form for achieving analgesic concentrations is not well defined. The primary aim of this pilot project was to study the early bioavailability for two fixed doses of orally administrated paracetamol and one dose of intravenous propacetamol, all of which were given after minor surgery. ⋯ Oral administration of paracetamol as part of multimodal pain management immediately post-operatively resulted in a huge and unpredictable variation in plasma concentration compared with the intravenous administration.
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Acta Anaesthesiol Scand · Aug 2004
Randomized Controlled Trial Clinical TrialNitrous oxide increases the incidence of bowel distension in patients undergoing elective colon resection.
Nitrous oxide rapidly inflates gas-filled spaces such as the intestines; but whether the resulting bowel distension is clinically important remains unclear. We therefore tested the hypothesis that nitrous oxide produces clinically important bowel distension. ⋯ Our results suggest that avoiding nitrous oxide administration during prolonged bowel operations will minimize bowel distension and possibly reduce postoperative pain related to it.