Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Nov 2008
Randomized Controlled TrialEffect of intraoperative magnesium sulphate infusion on pain relief after laparoscopic cholecystectomy.
The aim of the study is to evaluate the analgesic efficiency of perioperative magnesium sulphate infusion in patients undergoing laparoscopic cholecystectomy (LC). ⋯ Per-operative 50 mg/kg magnesium sulphate infusion is effective in reducing post-operative pain in patients undergoing LC.
-
Acta Anaesthesiol Scand · Nov 2008
Randomized Controlled Trial Comparative StudyEpidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in children.
Studies comparing epidural fentanyl and sufentanil in adults reported a similar analgesic effect with variable side effects. We hypothesized that epidural fentanyl and sufentanil will have a similar analgesic effect in children undergoing urological surgery. ⋯ Epidural sufentanil provides better analgesia from 24 h after surgery compared with epidural fentanyl in infants and children undergoing urological surgery. The incidence of pruritus in the sufentanil group was higher than that in the fentanyl group.
-
Acta Anaesthesiol Scand · Nov 2008
Randomized Controlled TrialItraconazole, a potent inhibitor of P-glycoprotein, moderately increases plasma concentrations of oral morphine.
Individual variation in opioid response is considerable, partly due to pharmacokinetic factors. Transporter proteins are becoming increasingly interesting also in the pharmacokinetics of opioids. The efflux transporter P-glycoprotein can affect gastrointestinal absorption and tissue distribution, particularly brain access of many opioids. The aim of this study was to evaluate whether itraconazole, which is a potent inhibitor of P-glycoprotein and CYP3A4, would change the pharmacokinetics or the pharmacodynamics of oral morphine. ⋯ Itraconazole moderately increases plasma concentrations of oral morphine, probably by enhancing its absorption by inhibiting intestinal wall P-glycoprotein. A possible improvement of morphine penetration to the brain could not be observed.
-
Acta Anaesthesiol Scand · Nov 2008
Randomized Controlled TrialEffect of magnesium sulfate on extubation time and acute pain in coronary artery bypass surgery.
Post-operative pain control is one of the greatest concerns for both physicians and patients. In this study, the effect of magnesium sulfate (MgSO(4)) solution infusion on post-operative pain scores and extubation time in patients undergoing elective coronary artery bypass graft (CABG) surgeries was assessed. ⋯ The results demonstrated a significantly shortened post-operative time for extubation and reduced acute post-operative pain scores by intravenous MgSO(4) infusion during elective CABG surgery.
-
Acta Anaesthesiol Scand · Nov 2008
Case ReportsThree-dimensional ultrasound-assisted popliteal catheter placement revealing aberrant anatomy: implications for block failure.
The current means of introducing continuous sciatic catheters include nerve stimulation, with or without catheter stimulation techniques. More recently, ultrasound has been utilized to facilitate catheter placement. ⋯ Because of this case observation, our current practice is to use ultrasound confirmation of the bifurcation of the nerve of all popliteal catheter placements, particularly catheters placed in patients having ambulatory procedures to prevent secondary failure of catheters at home.