Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2010
Randomized Controlled Trial Comparative StudyEndotracheal tube size and sore throat following surgery: a randomized-controlled study.
Women experience less frequent and less severe sore throat postoperatively after intubation with a size 6.0 ETT versus size 7.0.
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Acta Anaesthesiol Scand · Feb 2010
Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia.
Oxycodone is a semi-synthetic opioid with a mu-receptor agonist-mediated effect in several pain conditions, including post-operative pain. Oxycodone is metabolized to its active metabolite oxymorphone by O-demethylation via the polymorphic CYP2D6. The aim of this study was to investigate whether CYP2D6 poor metabolizers (PMs) yield the same analgesia post-operatively from intravenous oxycodone as extensive metabolizers (EMs). ⋯ This study showed for the first time in patients that the oxymorphone formation depends on CYP2D6, but we found no difference in the post-operative analgesic effect of intravenous oxycodone between the two CYP2D6 genotypes.
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Acta Anaesthesiol Scand · Feb 2010
Randomized Controlled Trial Comparative StudySparing the larynx during gynecological laparoscopy: a randomized trial comparing the LMA Supreme and the ETT.
We designed a prospective randomized single-blind study to compare efficiency and post-operative upper airway morbidity when the laryngeal mask airway (LMA) Supreme is used as an alternative to the endotracheal tube (ETT). ⋯ We demonstrated that choosing an LMA Supreme was an efficient pharyngolaryngeal morbidity-sparing strategy. Moreover, we showed that the LMA Supreme and the ETT were equally effective airways for a routine gynecological laparoscopy procedure.
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Acta Anaesthesiol Scand · Feb 2010
Randomized Controlled Trial Comparative StudyLate sensory function after intraoperative capsaicin wound instillation.
Intense capsaicin-induced C-fiber stimulation results in reversible lysis of the nerve soma, thereby making capsaicin wound instillation of potential interest for the treatment of post-operative pain. Clinical histological and short-term sensory studies suggest that the C-fiber function is partly re-established after skin injection of capsaicin. However, no study has evaluated the long-term effects of wound instillation of purified capsaicin on sensory functions. ⋯ This small-volume study calls for further long-term safety studies of wound capsaicin instillation.
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Acta Anaesthesiol Scand · Feb 2010
Randomized Controlled Trial Comparative StudyModafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
Early recovery of patients following sedation/analgesia and anesthesia is important in ambulatory practice. The aim of this study was to assess whether modafinil, used for the treatment of narcolepsy, improves recovery following sedation/analgesia. ⋯ Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve recovery in terms of objective measures of patient psychomotor skills.