Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2013
Comparative StudySevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats.
Patients with Alzheimer's disease (AD) exhibit a failure in the clearance of amyloid β peptides (Aβ) from the central nervous system. Previous studies have suggested an association between anesthesia and the occurrence of AD. The aim of the present report was to further explore this possibility. ⋯ Sevoflurane leads to a reduction in the levels of LRP-1, while increasing RAGE and decreasing IDE and NEP in both aged and, to a lesser extent, young rat's brain. These receptor and enzymatic changes may promote the accumulation of Aβ in brain tissues and thus exacerbate Alzheimer's-like pathology.
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Acta Anaesthesiol Scand · Aug 2013
Multicenter StudyAcute kidney injury in patients with severe sepsis in Finnish Intensive Care Units.
Severe sepsis is one of the leading causes of acute kidney injury (AKI). Patients with sepsis-associated AKI demonstrate high-hospital mortality. We evaluated the incidence of severe sepsis-associated AKI and its association with outcome in intensive care units (ICUs) in Finland. ⋯ More than half of the patients with severe sepsis had AKI according to the KDIGO classification, and AKI stage 3 was independently associated with 90-day mortality.
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Acta Anaesthesiol Scand · Aug 2013
Randomized Controlled Trial Comparative StudySevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol.
Cirrhotic patients are prone to developing renal dysfunction after anaesthesia and surgery. However, no consensus has been reached whether sevoflurane could have adverse effects on renal function in cirrhotic patients. We hypothesised that the use of sevoflurane for general anaesthesia would lead to post-operative renal dysfunction in cirrhotic patients undergoing liver resection. ⋯ Sevoflurane does not seem to impair post-operative renal function in cirrhotic patients undergoing liver resection.
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Acta Anaesthesiol Scand · Aug 2013
Comparative Study Clinical TrialPredicting haemorrhage in pre-hospital traumatic patients: evaluation of the novel heart-to-arm time index.
Early recognition of hypovolaemia in trauma patients is very important. However, the most often used clinical signs, such as hypotension and tachycardia, lack specificity and sensitivity. ⋯ iHAT is a non-invasive index that can identify haemorrhage in trauma patients with high sensitivity and specificity. These data should be considered as an exploration, but any conclusion should be validated in a new set of consecutive patients.