Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Mar 2015
Intraosseous and intravenous administration of antibiotics yields comparable plasma concentrations during experimental septic shock.
We aimed to investigate whether comparable antibiotic concentrations could be reached with intraosseous and intravenous administration during septic shock. ⋯ In this porcine septic shock model, intraosseous and intravenous administration of gentamicin and cefotaxime yielded comparable concentrations. In an emergency, intraosseous administration of these antibiotics may be considered in severe infections when venous access is difficult.