Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Mar 2015
Randomized Controlled TrialIntravenous lidocaine increases the depth of anaesthesia of propofol for skin incision - a randomised controlled trial.
The anaesthetic potency of intravenous propofol is quantified by its Cp50 value, which is defined as the plasma concentration required to prevent movement response in 50% of patients to surgical stimuli. We hypothesised that, in addition to propofol anaesthesia, an intravenous bolus of lidocaine 1.5 mg/kg will decrease the Cp50 value of propofol during anaesthesia. ⋯ An intravenous bolus injection of 1.5 mg/kg lidocaine 2% caused a significant reduction of the propofol Cp50 value.
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Acta Anaesthesiol Scand · Mar 2015
Randomized Controlled Trial Comparative StudyTotal intravenous general anaesthesia vs. spinal anaesthesia for total hip arthroplasty: a randomised, controlled trial.
The choice of anaesthetic technique for patients undergoing joint arthroplasty is debatable. The hypothesis of this study was that general anaesthesia would generate a more favourable recovery profile than spinal anaesthesia. ⋯ General anaesthesia resulted in a more favourable recovery profile compared with spinal anaesthesia.
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Acta Anaesthesiol Scand · Mar 2015
Randomized Controlled TrialAcute kidney injury with hydroxyethyl starch 130/0.42 in severe sepsis.
We aimed to detail the effects of hydroxyethyl starch (HES) vs. Ringer's on kidney function including the interaction with mortality in post-hoc analyses as resuscitation with HES 130/0.42 increased mortality in the Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial. ⋯ In patients with severe sepsis, HES appeared to increase the rate of severe AKI and use of RRT within the first 5 days. The increased mortality observed with HES may have been partly mediated through acute kidney impairment.