Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 2015
Arterial pressure during cardiopulmonary bypass is not associated with acute kidney injury.
Acute kidney injury (AKI) after cardiac surgery is common and is associated with increased mortality. We wanted to investigate if the arterial pressure or the use of norepinephrine during cardiopulmonary bypass were associated with AKI. ⋯ No independent relationship between arterial pressure or use of norepinephrine and AKI was found.
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Acta Anaesthesiol Scand · May 2015
Association of CYP450 single nucleotide polymorphisms with the efficacy of epidural ropivacaine during mastectomy.
Ropivacaine is frequently used for local anesthesia in the clinic and is metabolized by cytochrome P450 (CYP450) in the liver. CYP450 polymorphisms may alter the therapeutic efficacy of drugs in patients. In this study, we selected six CYP450 polymorphisms from the dbSNP and HapMap databases, using a combination of functional analysis and Tag SNP strategies and examined these polymorphisms for association with the efficacy of epidural ropivacaine in patients during mastectomy. ⋯ Our present data demonstrate that CYP1A2 SNPs rs11636419 and rs17861162 alter the sensitivity of epidural ropivacaine in patients undergoing breast cancer surgery. As such, detection of these two CYP1A2 SNPs may aid in the development of effective personalized treatments for breast cancer patients.
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Acta Anaesthesiol Scand · May 2015
Randomized Controlled TrialEffect of high-volume systematic local infiltration analgesia in Caesarean section: a randomised, placebo-controlled trial.
Local infiltration with either 50mL 0.5% or 125mL 0.2% ropivacaine did not improve post-operative pain after elective caesarean section.
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Acta Anaesthesiol Scand · May 2015
Review Meta AnalysisCentral venous pressure: we need to bring clinical use into physiological context.
The place of central venous pressure (CVP) measurement in acute care has been questioned during the past decade. We reviewed its physiological importance, utility and clinical use among anaesthetists and intensivists. ⋯ The correct measurement of CVP is pivotal to its proper clinical application. This relates to defining the pressure gradient for venous return and heart efficiency. The clinical appreciation of CVP should be restored by educational efforts of its physiological context.