Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Sep 2019
Multicenter StudyGenetic polymorphisms and prediction of chronic post-surgical pain after hysterectomy-a subgroup analysis of a multicenter cohort study.
Chronic post-surgical pain (CPSP) is a serious problem. Clinical and psychological variables have not been able to explain all observed variance in prevalence and severity of CPSP. The first objective is to determine the association between genetic polymorphisms and the prevalence of CPSP after hysterectomy. The second objective is to analyze if the implementation of genetic polymorphisms into a previously performed clinical and psychological predictor analysis on the development of CPSP after hysterectomy will improve its discriminatory power. ⋯ The rs4818 polymorphism within the COMT gene was associated with the prevalence of CPSP 3 months after hysterectomy, but the implementation of rs4818 into the prediction model did not significantly improve the chance of identifying hysterectomy patients at risk for CPSP.
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Acta Anaesthesiol Scand · Sep 2019
Rational application of antibiotics-The influence of anaesthetists' gender on self-confidence and knowledge.
High rates of multiresistant pathogens require detailed knowledge about rational utilization of antibiotics. Many physicians consider themselves uncertain about the interpretation of microbiological diagnostics. We examined whether self-confidence, self-rated knowledge, and objective knowledge regarding the use of antibiotics are associated with gender. ⋯ Less self-confidence and a lower self-rated knowledge were found in female anaesthetists; this is consistent to the gender phenomena observed by other researchers. Nevertheless, between the 2 groups objective knowledge did not differ significantly in any item.
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Acta Anaesthesiol Scand · Sep 2019
Risk factors for post-operative pulmonary complications in lung cancer patients after video-assisted thoracoscopic lung resection: Results of the German Thorax Registry.
Post-operative pulmonary complications (PPCs) represent the most frequent complications after lung surgery. The aim of this study was to identify the modifiable risk factors for PPCs after video-assisted thoracoscopic surgery (VATS) in lung cancer patients. ⋯ Intraoperative amount of crystalloid fluids should be kept below 6 mL/kg/h and duration of surgery should be below 2 hours to avoid an increased risk for PPCs.
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Acta Anaesthesiol Scand · Sep 2019
Review Meta AnalysisQuinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis.
Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis. ⋯ This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.
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Acta Anaesthesiol Scand · Sep 2019
Review Comparative StudyRoutine vs on-demand blood sampling in critically ill patients-Protocol for a scoping review.
In intensive care units, blood sampling is done commonly as part of daily routine. It remains unknown whether this practice is associated with harms or benefits, as not all routine blood tests may be clinically indicated, and blood sampling done without specific indications may be problematic. Accordingly, we aim to assess the body of evidence regarding the usage of routine vs on-demand blood sampling in critically ill patients in a scoping review. ⋯ The outlined scoping review will provide an important overview on the current body of evidence regarding the use of daily routine vs on-demand blood sampling in critical care settings. The findings of this scoping review will guide further research.