Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jun 1980
Comparative StudyCyclic AMP and metabolic substrates following hemorrhage in awake and anesthetized rats.
The levels of several metabolites in plasma were studied during a period of 4 h in awake and barbiturate anesthetized rats after a blood volume loss of approximately 3% of b.w. Blood pressure was 70 mmHg (9.3 kPa) in the awake and 35 mmHg (4.7 kPa) in the anesthetized rats. Resting levels of plasma glucose, blood lactate and pyruvate and plasma cyclic AMP were higher in the awake rats than in the anesthetized rats. ⋯ The initial changes in plasma metabolite levels appeared to be directly related to changes in plasma catecholamine levels. There were no differences in the relationship between the adrenaline level and cyclic AMP or glucose increase, suggesting that anesthesia did not alter beta-adrenoceptor sensitivity, but only catecholamine concentrations. The results also indicate that awake rats tolerate long-lasting blood volume loss better than anesthetized rats, because the sympatho-adrenal activation is more short-lasting.
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Acta Anaesthesiol Scand · Jun 1980
Anesthesia for cesarean section.--VI Late effects on the infant of enflurane anesthesia for cesarean section.
Enflurane anesthesia for cesarean section has given favourable results with regard to anesthetic effect and lack of depression of the neonate. Enflurane is metabolized to fluoride. High serum levels of inorganic fluoride are nephrotoxic. ⋯ To exclude unwanted effects on the children, a follow-up study was undertaken 6-12 months after delivery. General development and renal function were studied. No abnormalities were found, indicating that enflurane anesthesia for cesarean section has no persistent unfavourable effects on the children.
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Acta Anaesthesiol Scand · Apr 1980
The ejector flowmeter as air/oxygen mixing device. An apparatus providing gas mixtures with adjustable oxygen content for high-flow humidification systems.
The ejector flowmeter is constructed for continuous removal of excess gas from anaesthetic circuits. This instrument can be used as an air/oxygen mixing device for high-flow humidification systems in wards where compressed air is not available. Pure oxygen is used as driving gas through the ejector. A nomogram has been constructed to show the relationship between oxygen driving pressure, inlet of air to the flowmeter, FIO2 and total outflow.
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Acta Anaesthesiol Scand · Jan 1980
Calculation of the fresh gas flow requirements of the Hafnia A and D anaesthetic circuits.
Semi-closed anaesthetic circuits are converted into the corresponding Hafnia circuits by replacing the expiratory valve by a side tube connected to an ejector flowmeter. Theoretical analysis of the Hafnia A and D circuits revealed by the fresh gas flow requirements are dependent on the inspiration/expiration time ratio. Using a ratio of 1/1.2 and a sine-wave respiratory waveform, the minimal fresh gas requirements were calculated as 2.1 (Hafnia A) and 2.5 (Hafnia D) times the respiratory minute volume. The fresh gas requirements are identical with spontaneous or controlled ventilation.
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Acta Anaesthesiol Scand · Jan 1980
Comparative StudySister chromatid exchanges in lymphocytes in operating room personnel.
Sister chromatid exchanges (SCE) and sister chromatid exchange points (SCE-points) were counted in lymphocytes in peripheral blood drawn from hospital personnel exposed to anesthetics as well as from persons not exposed. A total of 38 healthy persons were investigated, representing female nurse anaesthetists, male physicians practising anaesthesia, female nurses from the intensive care unit, and female secretaries. ⋯ Correlation of cigarette smoking and number of SCE could not be demonstrated (r=0.255, n=38). It was concluded that by this method there was no indication of a mutagen effect of long-term exposure to waste anaesthetic gases such as halothane and nitrous oxide.