Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Mar 2002
Meta AnalysisDimenhydrinate for prophylaxis of postoperative nausea and vomiting: a meta-analysis of randomized controlled trials.
Diphenhydramine and its theoclate salt dimenhydrinate are traditional antiemetics still in use. However, so far the quantitative effect of dimenhydrinate in the prophylaxis of postoperative nausea and vomiting (PONV) has not been evaluated systematically. ⋯ Dimenhydrinate is a traditional and inexpensive antiemetic with an efficacy that might be considered as clinically relevant. Although in use for a long time, the dose-response, precise estimation of side-effects, optimal time of administration and the benefit of repetitive doses still remain unclear.
-
Acta Anaesthesiol Scand · Sep 2001
Meta AnalysisAssessment of the efficacy of esmolol on the haemodynamic changes induced by laryngoscopy and tracheal intubation: a meta-analysis.
Adrenergic stress response induced by laryngoscopy and tracheal intubation (LTI) appears to be attenuated by esmolol, but its potential clinical benefits have not been fully weighed against possible adverse effects. ⋯ Esmolol is effective, in a dose-dependent manner, in the attenuation of the adrenergic response to LTI. To minimise its adverse effects it should be administered, when considered clinically appropriate, as a continuous infusion regimen.
-
Acta Anaesthesiol Scand · Aug 2001
Meta AnalysisEfficacy and safety of patient-controlled opioid analgesia for acute postoperative pain. A quantitative systematic review.
The usefulness of intravenous patient-controlled analgesia (PCA) with opioids for postoperative analgesia is not well defined. ⋯ These trials provide some evidence that in the postoperative pain setting, PCA with opioids, compared with conventional opioid treatment, improve analgesia and decrease the risk of pulmonary complications, and that patients prefer them.
-
Acta Anaesthesiol Scand · Jul 2001
Meta AnalysisThe influence of a dominating centre on a quantitative systematic review of granisetron for preventing postoperative nausea and vomiting.
We performed a meta-analysis on granisetron in the prevention of postoperative nausea and vomiting (PONV) and further investigated whether total results and the dose-response characteristics may be significantly affected by a single centre. ⋯ Overall results and dose-response characteristics of meta-analyses may be significantly altered by one dominating centre. Further, if data of a dominating centre do not appear to be valid for other centres, it may seem advisable to either exclude them from the analysis or to perform sub-group analyses so that results without the data from the dominating centre are available.
-
Acta Anaesthesiol Scand · Feb 2001
Meta AnalysisAn increased body mass index is no risk factor for postoperative nausea and vomiting. A systematic review and results of original data.
An increased Body Mass Index (BMI) is almost always mentioned as a fundamental risk factor for postoperative nausea (PN), vomiting (PV) or both (PONV). However, multivariate analyses were unable to detect any correlation. Therefore, we asked whether an increased BMI is really a risk factor for PONV. ⋯ Systematic search of the literature provides no evidence for a positive relationship. Furthermore, our data confirm that an increased BMI is not a risk factor for PONV. This negative finding is important as focussing on the relevant risk factors is needed to allow for an objective risk assessment of PONV.