Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 1998
Randomized Controlled Trial Comparative Study Clinical TrialWaste gas exposure during desflurane and isoflurane anaesthesia.
Currently, there are no data available concerning the occupational exposure to desflurane during general anaesthesia. This prospective, randomized study reports on occupational exposure to desflurane, compared to isoflurane, in a modern operation theatre (OT). ⋯ Occupational exposure to desflurane is low in the environment of a modern OT, even though it has to be administered in approximately 5-fold higher concentrations compared to isoflurane.
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Acta Anaesthesiol Scand · Aug 1998
Intrathoracic and pulmonary blood volume during CO2-pneumoperitoneum in humans.
Induction of CO2-pneumoperitoneum may have significant effects on systemic and pulmonary haemodynamics. We hypothesized that intrathoracic (ITBV) and pulmonary blood volume (PBV) are affected during intra-abdominal CO2-insufflation, which may be pronounced by positional changes of the patient. ⋯ In anaesthetized-paralyzed patients in the reverse Trendelenburg position intra-abdominal CO2-insufflation is associated with significant alterations of ITBV and PBV. The release of CO2-pneumoperitoneum is associated with a re-distribution of blood into the thorax.
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Acta Anaesthesiol Scand · Aug 1998
Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep.
Tizanidine (TZD) is an alpha-2-adrenergic drug with potential spinal analgesic action and could be a substitute or additive for intrathecal (i.t.) opiates in chronic pain treatment. However, long-term tolerability and tissue compatibility are not yet established. ⋯ The long-term intrathecal infusion of TZD is well tolerated and non-toxic in the sheep. The data favor clinical trials in patients with chronic pain.
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Acta Anaesthesiol Scand · Aug 1998
Inhibited hypothalamic histamine metabolism during isoflurane and sevoflurane anesthesia in rats.
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate the effects of isoflurane and sevoflurane anesthesia on hypothalamic histamine metabolism. ⋯ Histamine metabolism was inhibited during both isoflurane and sevoflurane anesthesia and accelerated only in the posterior hypothalamus during the emergence from these anesthetics.
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Acta Anaesthesiol Scand · Aug 1998
Randomized Controlled Trial Comparative Study Clinical TrialPostoperative analgesia with epidural bupivacaine and low-dose fentanyl--a comparison of two concentrations.
The purpose of the study was to compare the analgesic and side effects of two epidurally administered mixtures of bupivacaine and fentanyl with the same drug ratios. ⋯ Both groups had low pain scores with few and comparable adverse effects. It thus seems that the volume is not important when mixtures of bupivacaine and fentanyl in the studies concentrations are infused epidurally at a low thoracic level. Practical reasons favour the higher concentration mixture.