Journal of paediatrics and child health
-
J Paediatr Child Health · Feb 1994
Randomized Controlled Trial Comparative Study Clinical TrialAerosol deposition in cystic fibrosis using an aerosol conservation device and a conventional jet nebulizer.
The deposition of technetium radiolabelled aerosol within the lungs of 12 stable cystic fibrosis patients (mean age 12.7 years) was compared using the Acorn nebulizer and mouthpiece alone, and the Acorn nebulizer attached to the Mizer Aerosol Conservation Device (MACD). The total activity delivered to the patient using the MACD was 11.1% (+/- 7.8% s.d.) of the initial dose, compared to 5.8% (+/- 4.2% s.d.) with the nebulizer and mouthpiece alone (P < 0.05). ⋯ No significant correlation was found between aerosol deposition and pulmonary function. The Mizer Aerosol Conservation Device significantly increases both total intrapulmonary aerosol deposition and peripheral aerosol distribution.
-
Two cases of central nervous system germinoma are described which highlight the various presentations of this tumour in different anatomical locations. The first case is that of a 15 year old boy with a suprasellar germinoma who presented with the classical triad of diabetes insipidus, visual disturbance and hypopituitarism. ⋯ Both cases were treated with corticospinal irradiation which resulted in regression of the tumours. Follow up has now been for over 4 years with no sign of recurrence.