Neurología : publicación oficial de la Sociedad Española de Neurología
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Randomized clinical trials and mainly meta-analysis, have become the gold standard in the assessment of drug efficacy. A meta-analysis is a systematic review that uses statistical techniques to combine and summarize results of previous studies. ⋯ This type of meta-analysis avoids the partiality which may originate from the non-publication of nonsignificant studies. The future tendency would recommend that investigators, clinicians, reviewers, journal editors and sponsors agree on publication criteria other than positive p values such as clinical validity and clinical relevance.