Current opinion in oncology
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The present review focuses on recent progress in tumour immunology and immunotherapeutic trials in malignant gliomas. ⋯ Improvements in clinical methods and large randomized trials are now needed to prove the usefulness of cancer vaccines. Indeed, comprehensive analysis of tumour immunology and new immunization protocols suggest that immunotherapy can become an efficacious treatment in the near future. Combination with radiotherapy or chemotherapy should be investigated.
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The present review will describe progress in the utilization of epidermal growth factor receptor (EGFR) inhibitors in the treatment of nonsmall-cell lung cancer and the treatment of squamous cell carcinoma of the head and neck. Recent findings regarding clinical activity as well as markers associated with sensitivity to these agents will be reviewed. ⋯ These dramatic successes have led to further clinical studies of EGFR targeted therapy in aerodigestive malignancies, making a significant impact on the clinical care of patients with nonsmall-cell lung cancer and squamous cell carcinoma of the head and neck.