Leukemia & lymphoma
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Leukemia & lymphoma · Oct 2008
Multicenter StudyCytogenetic characterisation in Chinese patients with chronic lymphocytic leukemia: a prospective, multicenter study on 143 cases analysed with interphase fluorescence in situ hybridisation.
Chronic lymphocytic leukemia (CLL) is infrequent in Chinese people. Conventional cytogenetic analysis underestimates the frequency of chromosome aberrations in CLL due to the low rate of spontaneous mitoses. The aim of this study was to prospectively explore the frequency of chromosomal abnormalities in Chinese patients with CLL using interphase fluorescence in situ hybridisation (FISH) and probes for 12 centromere, 13q14, 14q32, 17p13, 11q22 and 6q23 on 143 patients with CLL. ⋯ In early stage (Binet A), del(13q14) aberration was more frequent than in Binet B and C (61.5% vs. 31.9% and 41.9%) (P=0.021). Patients with advanced stage (Binet C) had more frequent del(17p13) aberration than in Binet A and B (32.3% vs. 9.2% and 4.3%) (P=0.008). It was showed that the frequencies of the chromosomal abnormalities in our study population were similar to the frequencies in Western countries.
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Leukemia & lymphoma · Oct 2008
Outcome and prognostic factors of patients with acute leukemia admitted to the intensive care unit for septic shock.
The purpose of the present study was to evaluate outcomes and identify prognostic factors in patients with acute leukemia who were admitted to the intensive care unit (ICU) with septic shock. Medical records of 50 patients with acute leukemia who were treated for septic shock in the Medical ICU of Samsung Medical Centre between September 2001 and June 2006 were retrospectively reviewed. The data were analysed for patient outcomes and for predictors of ICU mortality. ⋯ In the multivariate analysis using the Cox-model, a relapsed/refractory status for leukemia and poor SOFA score were independent predictors for ICU mortality. In conclusion, although the mortality was high in patients with acute leukemia who were admitted to the ICU for septic shock management, it was not high enough to preclude intensive care. Patients with severe organ failure and a relapse/refractory status for leukemia had a significantly worse prognosis.