Leukemia & lymphoma
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Leukemia & lymphoma · Feb 2018
ReviewDiagnosis and management of smoldering multiple myeloma: the razor's edge between clonality and cancer.
Smoldering multiple myeloma (SMM) is a rare plasma cell disorder, and as the disease is asymptomatic, diagnosis is often incidental. SMM is characterized by increased marrow infiltration by clonal plasma cells and/or elevated serum M-protein in the absence of a myeloma-defining event (MDE). ⋯ In this review, we assess the risk factors and models for progression to multiple myeloma. A review of our diagnostic and management approaches to SMM is presented.