International psychogeriatrics
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Randomized Controlled Trial Clinical Trial
Psychosocial intervention for dementia caregivers: what can it accomplish?
Research has shown that psychosocial intervention can have a significant benefit for patients and caregivers. Randomized controlled trials of psychosocial intervention for spouse-caregivers can improve social support and reduce depression among the caregivers and help prevent or postpone nursing home placement of their spouses with Alzheimer's disease.
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Randomized Controlled Trial Clinical Trial
Patient populations in clinical studies of donepezil in vascular dementia.
There are difficulties in accurately defining patients with vascular dementia (VaD) and, therefore, little is known about the characteristics of this population. ⋯ The patients enrolled in these trials had probable or possible VaD; these patients exhibited a history of cerebrovascular disease and a broad range of comorbid cardiovascular conditions. The large number of patients enrolled will permit a thorough examination of the efficacy and tolerability of donepezil in VaD.
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Monogenic disorders account for only a minority of strokes. Yet, they have been particularly helpful in exploring basic disease mechanisms. This article summarizes some recent data on monogenic stroke while focusing on two conditions: CADASIL, as a genetic variant of ischemic small vessel disease, and familial forms of cerebral amyloid angiopathy, which share many properties with sporadic disease.