Neurosurgery clinics of North America
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The use of minimally invasive approaches to the anterior skull base is a valuable tool to improving the treatment in patients with aggressive anterior skull base neoplasms. This article discusses the history, advantages and disadvantages relative to open approaches, the corridors and pathways used in approach, the equipment and operating room setup, perioperative care, and complication avoidance. Although outcomes are difficult to compare to open approaches, due to often small and varying patient cohorts, these approaches continue to gain acceptance as an effective treatment of anterior skull base tumors in the experienced surgeon's hands with proper patient selection.
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Esthesioneuroblastoma is a rare malignant neoplasm in the olfactory region of the nasal cavity and anterior skull base. Diagnosis and staging require anatomic imaging and careful pathologic assessment. Standard treatment is anterior craniofacial resection with postoperative irradiation. ⋯ Prognosis is favorable; however, metastasis rates remain relatively high. Regional and distant metastasis portends a poor outcome. Intensity-modulated radiation treatment and endoscopic surgery have reduced morbidity, but outcomes with these techniques must be fully evaluated.
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Primary temporal bone tumors are rare. Suspicious lesions of the ear canal should be biopsied for diagnosis. Surgical resection to achieve negative margins is the mainstay of treatment. ⋯ Adjuvant postoperative radiotherapy has shown improved survival for some patients. Chemotherapy has an emerging role for advanced stage disease. Evaluation and management by a multidisciplinary team are the best approach for patients with these tumors.