Acta dermato-venereologica
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Acta Derm. Venereol. · Jan 1984
Loss of bullous pemphigoid antigen in peritumoral lacunas of basal cell carcinomas.
Peritumoral lacunas of basal cell carcinoma (BCC) were for a long time misinterpreted as fixation artifacts. However, recent studies showed that they might be considered as a dynamic process related to degenerescence for the palisade cells. We studied three antigens of the epidermal basement membrane zone--type IV collagen, laminin, and bullous pemphigoid antigen--by indirect immunofluorescence in six cases of basal cell carcinoma. ⋯ Bullous pemphigoid antigen showed either a linear continuous or discontinuous staining pattern along the basement membrane zone of the carcinomatous buds. At the site of a peritumoral lacuna bullous pemphigoid antigen abruptly disappeared. The loss of bullous pemphigoid antigen might be related to the lacuna formation.
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A mycological and immunological survey was performed in 26 patients with clinical signs of dermatophytid. Only 10 patients fulfilled the main criteria of dermatophytid reactions, i.e. positive delayed skin test to trichophytin and dermatophyte isolated by culture. ⋯ Relying on clinical appearance only implies an obvious risk of erroneously including pyoderma and various eczemas, e.g. pompholyx and contact dermatitis, as dermatophytids. Mycological culture and skin test with a reliable trichophytin antigen preparation ought to be applied in order to avoid misdiagnosis.
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A family genealogy, comprising four cases of familial multiple lipomatosis, making their appearance one after the other in three generations is reported. Two cases with impressive clinical features are presented in detail. This report contributes to the opinion that the disease is transmitted by the autosomal dominant route of inheritance.
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Acta Derm. Venereol. · Jan 1980
Case ReportsDisturbances in the metabolism of calcium and vitamin D in a case of sarcoidosis.
A case of subcutaneous nodular sarcoidosis presented low 25-hydroxy-vitamin D levels during the active phase of the disease, while the serum calcium levels were increased. During spontaneous remission both 25-OHD levels and serum calcium levels returned to normal.