Journal of cardiovascular electrophysiology
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J. Cardiovasc. Electrophysiol. · Apr 1996
ReviewPropafenone: an effective agent for the management of supraventricular arrhythmias.
Propafenone is a sodium channel blocking antiarrhythmic drug. It also has beta-adrenergic, potassium channel, and weak calcium channel blocking activity. The drug is metabolized in the liver with rates dependent on the debrisoquin phenotype. ⋯ The drug may produce SA block in patients with underlying sinus node dysfunction. Propafenone has comparatively few noncardiac side effects. It is a useful primary drug or an alternative to more commonly used drugs used for the treatment of supraventricular arrhythmias.