Archives of orthopaedic and trauma surgery
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Arch Orthop Trauma Surg · Sep 2003
Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing.
Nonsteroidal antirheumatics (NSAR; NSAID) are often used in patients with fractured bones for analgetic reasons. This animal experiment was performed to determine the influence of NSAR on the process of fracture healing. As an alternative, tramadol, the centrally acting analgetic without peripheral effects, was included in this experiment. ⋯ Oral application of diclofenac significantly delayed fracture healing in rats. This effect might be comparable to other NSAR and fracture healing in humans.
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Complications after pelvic sarcoma surgery are frequent; however, the reports on complications are limited. Results of the authors' experience with 110 primary pelvic tumor resections and methods to achieve low complication rates for pelvic reconstruction are reported. ⋯ Because of the small number of complications and good function, autograft implantation after iliac resection and hip transposition after acetabular resection are advisable.