Coronary artery disease
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Coronary artery disease · Jan 1996
Randomized Controlled Trial Clinical TrialImprovement of exercise-induced ischaemia and myocardial perfusion after aminophylline.
Previous studies have suggested that aminophylline improves exercise-induced ischaemia by preventing the redistribution of the coronary flow from ischaemic to non-ischaemic myocardium. The purpose of the study was to assess whether aminophylline improves myocardial perfusion in zones supplied by collateral circulation. ⋯ Aminophylline significantly delayed the time to onset of exercise-induced ischaemia and improved perfusion in zones supplied by collateral circulation. Aminophylline-like drugs may be useful in the treatment of selected patients with ischaemic heart disease.