Coronary artery disease
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Coronary artery disease · Mar 2005
Comparative StudyFeasibility and safety of regional myocardial hypothermia during myocardial ischemia and infarction in pigs.
Mild systemic hypothermia has been shown to be feasible and safe in patients during acute myocardial infarction (AMI). Regional myocardial hypothermia of the ischemic myocardium only may be more effective in myocardial salvage with fewer side effects compared with systemic hypothermia. The purpose of this study was to evaluate the feasibility and safety of regional myocardial hypothermia in pigs. ⋯ It is feasible and safe to achieve regional myocardial hypothermia by intracoronary infusion of cooled solution in pigs.