Coronary artery disease
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Coronary artery disease · Jan 2015
ReviewQuality improvement in acute coronary syndromes: translating evidence into practice.
Despite the substantial progress in elucidating the pathophysiology of acute coronary syndromes (ACS) and developing an array of therapeutic advances for the management of these conditions, several challenges still persist. The use of guideline recommendations for the care of patients with ACS by both healthcare providers and hospitals can improve short-term and long-term outcomes and potentially reduce healthcare costs. ⋯ Several quality improvement programs, by both governmental and nongovernmental organizations, have been developed in an attempt to encourage maximal utilization of evidence-based interventions. In this review, we will examine the evidence for the importance of guideline adherence in the management of ACS, explore predictors of adherence to these guidelines, and provide evidence-based strategies for improving their implementation.
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Coronary artery disease · Jan 2015
Controlled Clinical TrialPharmacodynamic effects during the transition between cangrelor and prasugrel.
The aim of this study was to determine the impact of cangrelor and prasugrel on the pharmacodynamic effects of each agent. ⋯ Prasugrel did not alter the antiplatelet effects of cangrelor, but transient recovery of platelet reactivity was apparent during the transition from cangrelor to prasugrel. Recovery of platelet reactivity was limited when prasugrel was administered 30 min before the end of the cangrelor infusion.